Evaluation of serum bilirubin and alkaline phosphatase levels in patients with cardiovascular disease

Context: The enhanced inflammatory response and oxidative stress may play an important role, apart from classic risk factors like hypertension and diabetes mellitus, in the cardiovascular morbidity and mortality. Aims: To evaluate the role of serum bilirubin and alkaline phosphatase levels in cardiovascular diseases. Settings and Design: Study type is observational randomized controlled trials. Study group includes 100 CVD patients. Methods and Material: All the parameters are analyzed on Olympus AU 400 fully automated random access analyzer. Statistical analysis : We analysed the data using student t test and Pearson’s correlation. Statistical software used was graphpad prism. Results: Mean serum levels of bilirubin were lower in patients with cardiovascular diseases compared to control group. Serum alkaline phosphatase levels were comparatively higher in patients than in control group. These levels were statistically significant (p<0.005) and were corresponding to dyslipidemia and inflammatory status in these patients. Conclusions: Lower levels of serum bilirubin indicate that there was an independent inverse association between serum total bilirubin and cardiovascular disease.Elevated alkalinephosphatase levels were associated with cardiovascular disease considering it as a cost effective diagnostic marker. Further research is needed to evaluate the effects of agents altering levels of serum bilirubin levels and alkalinephosphatase to decrease mortality.